Modeling decline in cognition to decline in function in Alzheimer's disease

 
   Lead Investigator:    Noemi Hummel
   Institution      :    Analytica Laser
   E-Mail           :    n.hummel@analytica-laser.com
   Proposal ID      :    989



   Proposal Description:
   The aim of this project is to establish the time-dependent relationship between cognitive and functional decline in Alzheimer?s disease using longitudinal real-world databases. The envisioned model structure will be a generalized linear or a non-linear mixed-effects model to link cognition to function, incorporating relevant covariates and within- and between patient variability. Its aim will be to predict the functional outcome at time t, accounting for the full time course of the preceding cognitive decline between time 0 and t.